| Comments |
Reference. Kim H, Kim JH, Lim JS, Choi JY, Chung YE, Park MS, Kim MJ, Kim KW, Kim SK. MRI Findings of Rectal Submucosal Tumors. Korean J Radiol. 2011 Jul-Aug;12(4):487-498. https://doi.org/10.3348/kjr.2011.12.4.487
Gastrointestinal Stromal Tumor Gastrointestinal stromal tumors harbor kit mutations that cause the overexpression of kit protein (CD 117) and these tumor show differentiation toward (or they are derive from) interstitial cells of Cajal. The malignant potential (very low, low, intermediate and high risk) depends on the mitotic rate and the size of the tumor (1). The sites most commonly involved by GIST are the stomach (60-70%) and small intestine (20-25%), with about 5% of all GISTs arising at the rectum (2). It is generally agreed that complete surgical resection with negative tumor margins is the principal curative procedure for primary, non-metastatic tumors. Gastrointestinal stromal tumors are usually seen as an eccentric mural mass with welldefined tumor margins. Calcification, necrosis and ulceration may be observed in the intermediate and high-risk tumors (3). The MRI features described for rectal GISTs are well-defined masses with low signal intensity on T1WI, they are hyperintense or isointense with hyperintense areas on T2WI and they exhibit marked heterogeneous enhancement after gadolinium administration (3). Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, et al. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002;33:459R11;465.
Grassi N, Cipolla C, Torcivia A, Mandala S, Graceffa G, Bottino A, et al. Gastrointestinal stromal tumour of the rectum: report of a case and review of literature. World J Gastroenterol 2008;14:1302R11;1304.
Darnell A, Dalmau E, Pericay C, Musulen E, Martin J, Puig J, et al. Gastrointestinal stromal tumors. Abdom Imaging 2006;31:387R11;399.
|
